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Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes.
Neurophotonics ( IF 5.3 ) Pub Date : 2020-09-01 , DOI: 10.1117/1.nph.7.3.035007
Stacey L Gorniak 1 , Victoria E Wagner 2 , Kelly Vaughn 2 , Jonathan Perry 3 , Lauren Gulley Cox 1 , Arturo E Hernandez 2 , Luca Pollonini 3
Affiliation  

Significance: Deficits in sensorimotor function in persons with type II diabetes mellitus (PwDM) have traditionally been considered a result of peripheral nerve damage. Emerging evidence has suggested that factors outside of nerve damage due to type II diabetes mellitus, such as impaired hemodynamic function, contribute significantly to both sensory and motor deficits in PwDM. Aim: The focus of the current study was to evaluate functional cortical hemodynamic activity during sensory and motor tasks in PwDM. Approach: Functional near-infrared spectroscopy was used to monitor oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) across the cortex during sensory and motor tasks involving the hands. Results: Decline in HbO across sensory and motor regions of interest was found in PwDM with simultaneous deficits in manual motor tasks, providing the first evidence of functional cortical hemodynamic activity deficits relating to motor dysfunction in PwDM. Similar deficits were neither specifically noted in HbR nor during evaluation of sensory function. Health state indices, such as A1c, blood pressure, body mass index, and cholesterol, were found to clarify group effects. Conclusions: Further work is needed to clarify potential sex-based differences in PwDM during motor tasks as well as the root of reduced cortical HbO indices but unchanged HbR indices in PwDM.

中文翻译:

绝经后II型糖尿病女性感觉运动皮层的功能性神经影像学检查。

意义:II型糖尿病(PwDM)患者的感觉运动功能缺陷传统上被认为是周围神经损伤的结果。新兴证据表明,II型糖尿病导致的神经损伤以外的其他因素,例如血液动力学功能受损,对PwDM的感觉和运动功能障碍均起重要作用。目的:本研究的重点是评估PwDM的感觉和运动任务期间功能性皮层血液动力学活动。方法:在涉及手的感觉和运动任务期间,使用功能性近红外光谱法监测整个皮质的氧合血红蛋白(HbO)和脱氧血红蛋白(HbR)。结果:在PwDM中,跨感兴趣的感觉和运动区域的HbO下降,同时发生了手动运动任务的不足,提供了与PwDM中的运动功能障碍有关的功能性皮层血液动力学活动缺陷的第一个证据。HbR或感觉功能评估期间均未特别指出类似的缺陷。发现健康状态指数,例如A1c,血压,体重指数和胆固醇,以阐明群体效应。结论:需要做进一步的工作来阐明运动任务期间PwDM中潜在的基于性别的差异,以及PwDM中皮质HbO指数降低但HbR指数不变的根源。
更新日期:2020-09-11
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