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TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases.
Open Biology ( IF 5.8 ) Pub Date : 2020-09-02 , DOI: 10.1098/rsob.200099
Juliane Totzke 1 , Scott A Scarneo 1 , Kelly W Yang 1 , Timothy A J Haystead 1
Affiliation  

Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive TNF signalling can lead to hyper active downstream nuclear factor (NF)-κβ signalling in turn amplifying a cell's inflammatory response and exacerbating disease. Within the TNF intracellular inflammatory signalling cascade, transforming growth factor-β-activated kinase 1 (TAK1) has been shown to play a critical role in mediating signal transduction and downstream NF-κβ activation. Owing to its role in TNF inflammatory signalling, TAK1 has become a potential therapeutic target for the treatment of inflammatory diseases such as RA. This review highlights the current development of targeting the TNF-TAK1 signalling axis as a novel therapeutic strategy for the treatment of inflammatory diseases.



中文翻译:

TAK1:一种有效的肿瘤坏死因子抑制剂,用于治疗炎症性疾病。

异常的肿瘤坏死因子 (TNF) 信号传导是许多炎症性疾病的标志,包括类风湿性关节炎 (RA)、肠易激性疾病和狼疮。适应不良的 TNF 信号可导致过度活跃的下游核因子 (NF)-κβ 信号转而放大细胞的炎症反应并加剧疾病。在 TNF 细胞内炎症信号级联反应中,转化生长因子 β 活化激酶 1 (TAK1) 已被证明在介导信号转导和下游 NF-κβ 活化中发挥关键作用。由于其在 TNF 炎症信号传导中的作用,TAK1 已成为治疗 RA 等炎症性疾病的潜在治疗靶点。

更新日期:2020-09-02
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