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Histone deacetylase (Rpd3) regulates Drosophila early brain development via regulation of Tailless.
Open Biology ( IF 5.8 ) Pub Date : 2020-09-02 , DOI: 10.1098/rsob.200029
Paromita Das 1, 2 , Manika Pal Bhadra 1, 2
Affiliation  

Tailless is a committed transcriptional repressor and principal regulator of the brain and eye development in Drosophila. Rpd3, the histone deacetylase, is an established repressor that interacts with co-repressors like Sin3a, Prospero, Brakeless and Atrophin. This study aims at deciphering the role of Rpd3 in embryonic segmentation and larval brain development in Drosophila. It delineates the mechanism of Tailless regulation by Rpd3, along with its interacting partners. There was a significant reduction in Tailless in Rpd3 heteroallelic mutant embryos, substantiating that Rpd3 is indispensable for the normal Tailless expression. The expression of the primary readout, Tailless was correlative to the expression of the neural cell adhesion molecule homologue, Fascilin2 (Fas2). Rpd3 also aids in the proper development of the mushroom body. Both Tailless and Fas2 expression are reported to be antagonistic to the epidermal growth factor receptor (EGFR) expression. The decrease in Tailless and Fas2 expression highlights that EGFR is upregulated in the larval mutants, hindering brain development. This study outlines the axis comprising Rpd3, dEGFR, Tailless and Fas2, which interact to fine-tune the early segmentation and larval brain development. Therefore, Rpd3 along with Tailless has immense significance in early embryogenesis and development of the larval brain.



中文翻译:

组蛋白去乙酰化酶 (Rpd3) 通过调节 Tailless 来调节果蝇早期大脑发育。

Tailless 是果蝇大脑和眼睛发育的主要转录抑制因子和主要调节因子。Rpd3 是组蛋白去乙酰化酶,是一种既定的阻遏物,可与 Sin3a、Prospero、Brakeless 和 Atrophin 等共阻遏物相互作用。本研究旨在破译Rpd3果蝇胚胎分割和幼虫大脑发育中的作用。它描绘了Rpd3及其相互作用伙伴的无尾监管机制。Rpd3中的Tailless显着减少异等位基因突变胚胎,证实了 Rpd3 对于正常的 Tailless 表达是必不可少的。主要读数 Tailless 的表达与神经细胞粘附分子同系物 Fascilin2 (Fas2) 的表达相关。Rpd3 还有助于蘑菇体的正常发育。据报道,Tailless 和 Fas2 表达都拮抗表皮生长因子受体 (EGFR) 的表达。Tailless 和 Fas2 表达的减少突出表明 EGFR 在幼虫突变体中上调,阻碍了大脑发育。本研究概述了由 Rpd3、dEGFR、Tailless 和 Fas2 组成的轴,它们相互作用以微调早期分割和幼虫大脑发育。因此,Rpd3 与 Tailless 一起在幼虫脑的早期胚胎发生和发育中具有重要意义。

更新日期:2020-09-02
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