During our screening for microbial regulators of bone metabolism, a new compound, 6-ethoxy-5,6-dihydropenillic acid (1), was isolated together with a known and structurally related penicillic acid (2) from the culture broth of the soil-derived fungus Penicillium sp. BF-0343. The structure of 1 was elucidated by various spectroscopic data including nuclear magnetic resonance experiments. Compounds 1 and 2 dose-dependently inhibited bone morphogenetic protein–induced alkaline phosphatase activity in myoblasts with half-maximal inhibitory concentration values of 19.8 and 2.1 μM, respectively.

中文翻译：

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青霉酸同源物，一种由真菌青霉菌产生的成纤维细胞中BMP诱导的碱性磷酸酶活性的新抑制剂。BF-0343

在我们筛选骨骼代谢的微生物调节剂时，从土壤的培养液中分离出了一种新化合物6-乙氧基-5,6-二羟戊酸（1）以及一种与结构相关的已知青霉素（2），衍生真菌青霉属。BF-0343。通过包括核磁共振实验在内的各种光谱数据阐明了1的结构。化合物1和2剂量依赖性地抑制成骨细胞中骨形态发生蛋白诱导的碱性磷酸酶活性，半数抑制浓度分别为19.8和2.1μM。