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Araliachinoside A: A New Triterpene Glycoside From Aralia chinensis Leaves
Natural Product Communications ( IF 1.8 ) Pub Date : 2020-09-02 , DOI: 10.1177/1934578x20952756
Pham Hai Yen 1, 2 , Nguyen Thi Cuc 1 , Phan Thi Thanh Huong 1 , Nguyen Xuan Nhiem 1, 2 , Nguyen Thi Hoai 3 , Ho Duc Viet 3 , Bui Huu Tai 1, 2 , Nguyen Van Tuyen 4 , Chau Van Minh 1 , Phan Van Kiem 1, 2
Affiliation  

From the leaves of Aralia chinensis, 3 oleanane-type triterpene glycosides have been isolated, including 1 new glycoside, 3β,23-dihydroxyolean-12-ene-28-oic acid 3-O-β-d-glucopyranosyl-(1→3)-α-l-arabinopyranosyl-(1→3)-β-d-glucuronopyranoside 28-O-β-d-glucopyranosyl ester (named as araliachinoside A, 1), and 2 known ones, 3β,23-dihydroxyolean-12-ene-28-oic acid 3-O-α-l-arabinopyranosyl-(1→3)-β-d-glucuronopyranoside 28-O-β-d-glucopyronosyl ester (2) and 3β-hydroxyolean-12-ene-28-oic acid 3-O-β-d-glucurono pyranoside 28-O-β-d-glucopyronosyl ester (3). Their chemical structures were elucidated by using a combination of high-resolution electrospray ionization-mass spectrometry, 1-dimensional and 2-dimensional nuclear magnetic resonance spectral data, and by comparison with previous literature. Compounds 1-3 displayed cytotoxic activity toward KB and HepG2 cell lines with half-maximal inhibitory concentration values ranging from 8.1 ± 0.1 to 15.7 ± 0.3 µM in in vitro assay.



中文翻译:

Araliachinoside A:来自Aralia chinensis叶子的新的三萜糖苷

从叶楤木,齐墩果烷3型三萜糖苷已被分离,其中包括1个新的糖苷,3β,23 -二羟基土当归-12-烯-28-酸3 -O- β- d -glucopyranosyl-(1→3 ) - α --arabinopyranosyl-(1→3)-β- d -glucuronopyranoside 28 -O- β- d吡喃葡萄糖基酯(命名为araliachinoside A,1),和2分公知的,3β,23 -二羟基土当归12 -烯-28-油酸3 -O-α - 1-阿拉伯吡喃- (1→3) - d-葡糖醛酸吡喃糖苷28 -O -β-d -glucopyronosyl酯(2)和3β-hydroxyolean -12-烯-28-酸3 -O- β- d -glucurono吡喃糖苷28 -O- β- d -glucopyronosyl酯(3)。通过结合使用高分辨率电喷雾电离质谱,一维和二维核磁共振光谱数据并与以前的文献进行比较,阐明了它们的化学结构。在体外试验中,化合物1-3对KB和HepG2细胞系显示出细胞毒活性,其最大抑制浓度值的一半为8.1±0.1至15.7±0.3 µM。

更新日期:2020-09-02
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