Background: The fabrication of artificial cardiac tissue is an active area of research due to the shortage of donors for heart transplantation and for drug development. In our previous study, we fabricated vascularized three-dimensional (3D) cardiac tissue by layer-by-layer (LbL) and cell accumulation technique. However, it was not able to develop sufficient function because it was cultured on a hard plastic substrate.

中文翻译：

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使用人诱导的多能干细胞在胶原培养容器上制造的超敏感逐层 3D 心脏组织。

背景：由于用于心脏移植和药物开发的供体短缺，人造心脏组织的制造是一个活跃的研究领域。在我们之前的研究中，我们通过逐层 (LbL) 和细胞积累技术制造了血管化的三维 (3D) 心脏组织。然而，它无法发挥足够的功能，因为它是在硬塑料基质上培养的。