The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 expression was analyzed via multiple online databases and its association with clinical characteristics, prognosis and genetic alterations was identified using the original The Cancer Genome Atlas-liver hepatocellular carcinoma cohorts. DNA methylation sites and their prognostic values were analyzed using MethSurv. The correlations between BRCA1 and immune infiltration were investigated via Tumor Immune Estimation Resource. As results, BRCA1 was significantly upregulated in tumor tissues in multiple HCC cohorts. Besides, high BRCA1 expression was correlated with race, advanced T stage, clinical stage, poor tumor grade, MSI status, and worse prognosis. Notably, BRCA1 expression was positively correlated with infiltration levels of B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells. The current findings imply that BRCA1 is associated with prognosis and immune infiltration, laying foundations for in-depth research on the role of BRCA1 in HCC.

中文翻译：

---

BRCA1是一种新型的预后指标，可与肝细胞癌的免疫细胞浸润相关。

乳腺癌基因1（BRCA1）是一种肿瘤抑制因子，突变或表观遗传失活会增加乳腺癌发生的风险。目前的研究旨在探讨肝癌中BRCA1表达，预后与肿瘤免疫力之间的关系。在这项研究中，通过多个在线数据库分析了BRCA1的表达，并使用原始的The Cancer Genome Atlas-liver肝细胞癌队列鉴定了其与临床特征，预后和遗传改变的关系。使用MethSurv分析DNA甲基化位点及其预后价值。通过肿瘤免疫估计资源研究BRCA1与免疫浸润之间的相关性。结果，BRCA1在多个HCC队列的肿瘤组织中显着上调。除了，BRCA1高表达与种族，晚期T期，临床分期，肿瘤分级差，MSI状况和预后不良有关。值得注意的是，BRCA1表达与B细胞，CD4 + T细胞，CD8 + T细胞，嗜中性粒细胞，巨噬细胞和树突状细胞的浸润水平呈正相关。目前的发现暗示BRCA1与预后和免疫浸润有关，为深入研究BRCA1在肝癌中的作用奠定了基础。