The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, ADAM9 can not only participate in the degradation of extracellular matrix as a metalloprotease, but also mediate tumor cell adhesion through its deintegrin domain, which is closely related to tumor invasion and metastasis. It is widely expressed in a variety of tumor cells and can affect the proliferation, invasion and metastasis of related cancer cells. We provide our views on current progress, its increasing importance as a strategic treatment goal, and our vision for the future of ADAM9.

ADAMs 家族属于锌依赖性金属蛋白酶的跨膜蛋白超家族，由多个结构域组成。这些域具有独立但互补的功能，使它们能够参与多个生物过程。其中，ADAM9不仅可以作为金属蛋白酶参与细胞外基质的降解，还可以通过其去整合素结构域介导肿瘤细胞粘附，与肿瘤侵袭转移密切相关。它在多种肿瘤细胞中广泛表达，可影响相关癌细胞的增殖、侵袭和转移。我们提供了我们对当前进展的看法、其作为战略治疗目标的重要性日益增加，以及我们对 ADAM9 未来的愿景。