Abstract Amphiphilic photo and redox dual-stimuli-cleavable β-cyclodextrin-ferrocene supramolecules were synthesized through noncovalent interactions of ferrocene (Fc) and β-cyclodextrin (β-CD) born by 5-hydroxy-2-nitrobenzyl alcohol (ONB), a photodegradable linker between the β-CD and poly(4-substituted-ɛ-caprolactone) (PXCL n ) chain. The terminal host–guest MPEG-Fc/β-CD-ONB-PXCL n complex can formed micelles in the aqueous phase. The critical micelle concentration ranged from 3.16 to 11.50 mg L−1. The drug-loading content and drug entrapment efficiency of the complex were lower than those of the parent β-CD. When exposed to ultraviolet irradiation and hydrogen peroxide, complex micelles could dissociate and efficiently release the loaded drug. Nanoparticles exhibited almost no toxicity at concentrations up to 1000 μg mL−1. The uptake of doxorubicin-incorporated micelles by HeLa cells was faster than that of free doxorubicin within the first 5 min. DOX-loaded MPEG45-Fc/β-CD-ONB-PMCL23 micelles effectively inhibited the proliferation of HeLa cells with a half maximal inhibitory concentration (IC50) of 3.8 µg mL−1. Graphical Abstract

中文翻译：

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用于药物递送的光和氧化还原双重刺激响应 β-环糊精-二茂铁超分子

摘要 通过 5-羟基-2-硝基苯甲醇 (ONB) 产生的二茂铁 (Fc) 和 β-环糊精 (β-CD) 的非共价相互作用合成了两亲光和氧化还原双重刺激可裂解的 β-环糊精-二茂铁超分子。 β-CD 和聚（4-取代-ɛ-己内酯）（PXCL n ）链之间的可光降解接头。终端主客体 MPEG-Fc/β-CD-ONB-PXCL n 复合物可以在水相中形成胶束。临界胶束浓度范围为 3.16 至 11.50 mg L-1。该复合物的载药量和药物包封率低于母体β-CD。当暴露于紫外线照射和过氧化氢时，复合胶束可以解离并有效地释放负载的药物。纳米颗粒在高达 1000 μg mL-1 的浓度下几乎没有表现出毒性。在前 5 分钟内，HeLa 细胞对掺入多柔比星的胶束的吸收比游离多柔比星的吸收快。装载 DOX 的 MPEG45-Fc/β-CD-ONB-PMCL23 胶束有效抑制 HeLa 细胞增殖，半数抑制浓度 (IC50) 为 3.8 µg mL-1。图形概要