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Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity.
mSphere ( IF 4.8 ) Pub Date : 2020-09-02 , DOI: 10.1128/msphere.00622-20
Carolin Loos 1, 2 , Caroline Atyeo 1, 3 , Stephanie Fischinger 1, 4 , John Burke 1 , Matthew D Slein 1 , Hendrik Streeck 5 , Douglas Lauffenburger 2 , Edward T Ryan 6, 7, 8 , Richelle C Charles 7, 9 , Galit Alter 10
Affiliation  

The novel coronavirus, SARS-coronavirus (CoV)-2 (SARS-CoV-2), has caused over 17 million infections in just a few months, with disease manifestations ranging from largely asymptomatic infection to critically severe disease. The remarkable spread and unpredictable disease outcomes continue to challenge management of this infection. Among the hypotheses to explain the heterogeneity of symptoms is the possibility that exposure to other coronaviruses (CoVs), or overall higher capability to develop immunity against respiratory pathogens, may influence the evolution of immunity to SARS-CoV-2. Thus, we profiled the immune response across multiple coronavirus receptor binding domains (RBDs), respiratory viruses, and SARS-CoV-2, to determine whether heterologous immunity to other CoV-RBDs or other infections influenced the evolution of the SARS-CoV-2 humoral immune response. Overall changes in subclass, isotype, and Fc-receptor binding were profiled broadly across a cohort of 43 individuals against different coronaviruses—RBDs of SARS-CoV-2 and the more common HKU1 and NL63 viruses. We found rapid functional evolution of responses to SARS-CoV-2 over time, along with broad but relatively more time-invariant responses to the more common CoVs. Moreover, there was little evidence of correlation between SARS-CoV-2 responses and HKU1, NL63, and respiratory infection (influenza and respiratory syncytial virus) responses. These findings suggest that common viral infections including common CoV immunity, targeting the receptor binding domain involved in viral infection, do not appear to influence the rapid functional evolution of SARS-CoV-2 immunity, and thus should not impact diagnostics or shape vaccine-induced immunity.

中文翻译:

早期 SARS-CoV-2 和交叉冠状病毒免疫的演变。

新型冠状病毒 SARS-冠状病毒 (CoV)-2 (SARS-CoV-2) 在短短几个月内已造成超过 1700 万例感染,疾病表现从基本无症状感染到重症不等。显着的传播和不可预测的疾病结果继续挑战这种感染的管理。解释症状异质性的假设之一是,暴露于其他冠状病毒 (CoV) 或总体上对呼吸道病原体产生免疫力的能力更强,可能会影响对 SARS-CoV-2 免疫力的演变。因此,我们分析了多个冠状病毒受体结合域 (RBD)、呼吸道病毒和 SARS-CoV-2 的免疫反应,以确定对其他 CoV-RBD 或其他感染的异源免疫是否影响了 SARS-CoV-2 体液免疫反应的演变。亚类、同种型和 Fc 受体结合的总体变化在 43 个人的队列中进行了广泛的分析,这些人针对不同的冠状病毒——SARS-CoV-2 的 RBD 以及更常见的 HKU1 和 NL63 病毒。我们发现对 SARS-CoV-2 的反应随着时间的推移发生了快速的功能演变,以及对更常见的 CoV 的广泛但相对更随时间变化的反应。此外,几乎没有证据表明 SARS-CoV-2 反应与 HKU1、NL63 和呼吸道感染(流感和呼吸道合胞病毒)反应之间存在相关性。这些发现表明,常见的病毒感染包括常见的 CoV 免疫,靶向病毒感染中涉及的受体结合域,
更新日期:2020-09-02
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