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In-depth GC-MS/MS Fragmentation Analysis of Formestane and Evaluation of Mass Spectral Discrimination of Isomeric 3-Keto-4-ene Hydroxy Steroids.
Rapid Communications in Mass Spectrometry ( IF 2 ) Pub Date : 2020-09-02 , DOI: 10.1002/rcm.8937
Annette Sophie Kollmeier 1 , Xavier de la Torre 2 , Christian Müller 3 , Francesco Botrè 2 , Maria Kristina Parr 1
Affiliation  

The aromatase inhibitor formestane (4‐hydroxyandrost‐4‐ene‐3,17‐dione) is included in the World Anti‐Doping Agency’s List of Prohibited Substances in Sport. However, it also occurs endogenously as do its 2‐, 6‐ and 11‐hydroxy isomers. The aim of this study is to distinguish the different isomers using GC/EI‐MS for enhanced confidence in detection and selectivity for determination.

中文翻译:

甲酸甲酯的深入GC-MS / MS碎片分析和异美3-酮4-烯羟基类固醇的质谱鉴别评估。

芳香酶抑制剂福尔马坦(4-羟基雄烷-4-烯-3,17-二酮)被列入世界反兴奋剂机构的《运动中禁用物质清单》。但是,它也像2-,6-和11-羟基异构体一样内源性地发生。这项研究的目的是使用GC / EI-MS区分不同的异构体,以增强检测的信心和测定的选择性。
更新日期:2020-09-02
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