In this study, in situ polyurethane (PU) bionanocomposites of poly(ethylene glycol) (PEG)/poly(ε‐caprolactone) (PCL) polyols, bare cellulose nanocrystals (CNCs) and PCL‐grafted CNCs (G‐CNC) were synthesized with different contents of CNCs as cross‐linking agent to control the extent of phase separation. The effect of confining the chains between CNCs through urethane linkages and presence of PCL grafts on phase and crystallization behavior was evaluated. Crystallization and chemical networking were controlled to tune the shape fixity (SF) and recovery (SR) of the specimens, resulting in a SF of 100% for linear and PU nanocomposites of G‐CNC (0.5% and 1%) samples. The PU nanocomposite of G‐CNC (0.5%) was selected as the optimum sample with the highest SR of 100%. The effect of surface hydrophobicity on cellular behavior of Human Foreskin Fibroblast (as a normal cell) and HepG2 (as a cancerous cell) cells was evaluated. Cell adhesion analysis of the prepared samples indicated two different behaviors possibly due to the difference in the epigenetic nature of the cells and cellular integrin‐ based bonds showing a great potential for a variety of tissue engineering applications.

中文翻译：

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聚乙二醇/聚ε-己内酯和[聚ε-己内酯接枝]纤维素纳米晶体的刺激响应性聚氨酯生物纳米复合材料

在这项研究中，合成了聚（乙二醇）（PEG）/聚（ε-己内酯）（PCL）多元醇，裸纤维素纳米晶体（CNCs）和PCL接枝的CNCs（G-CNC）的原位聚氨酯（PU）生物纳米复合材料。具有不同含量的CNCs作为交联剂以控制相分离的程度。评估了通过氨基甲酸酯键限制CNC链之间的链和PCL接枝的存在对相和结晶行为的影响。控制结晶和化学网络以调节样品的形状固定性（SF）和恢复（SR），从而使G-CNC的线性和PU纳米复合材料（0.5％和1％）的SF为100％。选择G-CNC（0.5％）的PU纳米复合材料作为最佳样品，其最高SR为100％。评估了表面疏水性对人包皮成纤维细胞（作为正常细胞）和HepG2（作为癌细胞）细胞行为的影响。对准备好的样品进行的细胞粘附分析表明，两种不同的行为可能是由于细胞的表观遗传特性和基于细胞整合素的键的差异所致，在多种组织工程应用中显示出巨大的潜力。