Recently developed dark‐blood techniques such as Flow‐Independent Dark‐blood DeLayed Enhancement (FIDDLE) allow simultaneous visualization of tissue contrast‐enhancement and blood‐pool suppression. Critical to FIDDLE is the magnetization preparation, which accentuates differences between myocardium and blood‐pool. Here, we compared magnetization transfer (MT)‐preparation and T2‐preparation for use with FIDDLE. Variants of FIDDLE were developed with MT‐ or T2‐preparation modules and tested in 35 patients (11 at 1.5 T, 24 at 3 T). Images were acquired with each FIDDLE variant in an interleaved fashion 10 minutes after gadolinium administration with otherwise identical acquisition parameters. Images were visually and quantitatively assessed for artifacts and differences in right ventricle to left ventricle (RV‐to‐LV) blood‐pool suppression. Bright artifacts, reflecting incomplete blood‐pool suppression, were frequently observed in the left atrium with T2‐preparation FIDDLE at 1.5 and 3 T (82% and up to 100% of patients, respectively). MT‐preparation FIDDLE resulted in fewer patients with artifacts (0% at 1.5 T, 22% at 3 T; P < .01). Left atrial blood‐pool signal was significantly more homogeneous with MT‐preparation than with T2‐preparation at 1.5 and 3 T (P < .001 for all comparisons). Visibly different RV‐to‐LV blood‐pool suppression was observed with T2‐preparation in 36% of patients at 1.5 T and up to 94% at 3 T. In these patients, RV blood‐pool signal was elevated, reducing the conspicuity of the myocardial‐RV blood‐pool border. Conversely, there were no visible differences in RV‐to‐LV blood‐pool suppression with MT‐preparation. Quantitative assessment of differences in blood‐pool suppression and blood‐pool artifacts was consistent with visual analyses. We conclude that for dark blood–blood delayed‐enhancement imaging of the heart, MT‐preparation results in fewer bright blood‐pool artifacts and more uniform blood‐pool suppression than T2‐preparation.

中文翻译：

---

磁化转移制备和 T2 制备用于暗血延迟增强成像的比较。

最近开发的暗血技术，如 Flow-Independent Dark-blood DeLayed Enhancement (FIDDLE)，允许同时可视化组织对比度增强和血池抑制。FIDDLE 的关键是磁化准备，它突出了心肌和血池之间的差异。在这里，我们比较了与 FIDDLE 一起使用的磁化转移 (MT) 制备和 T2 制备。FIDDLE 的变体是使用 MT 或 T2 制备模块开发的，并在 35 名患者中进行了测试（11 名 1.5 T，24 名 3 T）。在钆给药后 10 分钟，使用每个 FIDDLE 变体以交错方式采集图像，否则采集参数相同。对图像进行视觉和定量评估，以确定右心室到左心室 (RV-to-LV) 血池抑制的伪影和差异。使用 T2 制备 FIDDLE 在 1.5 和 3 T（分别为 82% 和高达 100% 的患者）的左心房中经常观察到明亮的伪影，反映了不完全的血池抑制。MT 制备 FIDDLE 导致出现伪影的患者更少（1.5 T 时为 0%，3 T 时为 22%；P < .01)。在 1.5 和 3 T 时，MT 制备的左心房血池信号明显比 T2 制备更均匀（所有比较P < .001）。在 1.5 T 时，36% 的患者和 3 T 时高达 94% 的患者观察到 T2 制备明显不同的 RV-to-LV 血池抑制。在这些患者中，RV 血池信号升高，降低了心肌-RV 血池边界。相反，使用 MT 制备在 RV 到 LV 血池抑制方面没有明显差异。对血池抑制和血池伪影差异的定量评估与视觉分析一致。我们得出结论，对于心脏的暗血-血延迟增强成像， 与 T2 制备相比，MT 制备导致更少的明亮血池伪影和更均匀的血池抑制。