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The "Carbonyl Story" and Beyond; Experiences, Lessons and Implications.
ChemBioChem ( IF 3.2 ) Pub Date : 2020-09-02 , DOI: 10.1002/cbic.202000387
Roger Alberto 1
Affiliation  

Lessons in discovery and development: The way to bring a 99mTc imaging agent into and through clinical trials is a long one. Although “carbonyl technology” has been known for almost two decades, only one compound made it that far. The different reasons for this are discussed in the paper together with scientific developments inspired by but beyond the carbonyl technology.
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中文翻译:

“羰基物语”及以后;经验,教训和启示。

发现和开发的经验教训:将99m Tc成像剂引入临床试验并通过临床试验的方法是漫长的。尽管“羰基技术”已经被人们知道了将近二十年,但只有一种化合物能够做到这一点。本文讨论了造成这种情况的不同原因,以及受羰基技术启发但超出了羰基技术的科学发展。
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更新日期:2020-10-02
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