Maternal folic acid (FA) intake before and during early pregnancy reduces the risk for neural tube defects (NTDs); evidence suggests it may also reduce the risk for oral clefts, urinary defects, and cardiac defects. We sought to re‐examine the use of drugs, which affect folate metabolism, dihydrofolate reductase inhibiting (DHFRI) medications, and anti‐epileptic drugs (AEDs), in data collected in the post‐FA fortification era (1998+) in the Slone Birth Defects Study.

中文翻译：

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怀孕前和怀孕期间使用叶酸拮抗剂和特定出生缺陷的风险。

孕早期和孕早期摄入叶酸 (FA) 可降低神经管缺陷 (NTD) 的风险；有证据表明，它还可以降低口腔裂隙、泌尿系统缺陷和心脏缺陷的风险。我们试图重新检查影响叶酸代谢的药物、二氢叶酸还原酶抑制 (DHFRI) 药物和抗癫痫药物 (AED) 的使用，这些数据是在 Slone 的后 FA 强化时代（1998 年以上）收集的数据中。出生缺陷研究。