Abstract Hyaluronic acid (HA) as a major constituent of bionic synovial fluid (BSF) has significant role in lubrication of human body hip joint. Those who mostly suffer from joint related disease prefer to try injections of synovia over of total hip replacement (THR). However, affection of the metabolism process to the injected synovia is able to decrease the life time of the prostheses. In this study, injectable and thermosensitive agarose hydrogel as a carrier for hyaluronic acid has been investigated to extend the life time of the artificial hip joints. Experimental evidences reveal bioactivity, superior viscoelasticity and naturally amorphous network structure of the HA. This material in combination with the large molecules of agarose is able to create three-dimensional polymeric network for separating the conterminous surfaces of bearings and improve the lubrication with more than 30 % reduction rate for coefficient of the friction. Role of mechanical and rheological properties of designed polymeric network in cumulative sustained released of lubricants has been widely investigated. Novelty of the present work provides a survey to the long-term lubrication of artificial hip joints.

中文翻译：

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具有抗摩擦性能和增强人工关节稳定性的可释放琼脂糖透明质酸水凝胶

摘要 透明质酸（HA）作为仿生滑液（BSF）的主要成分，对人体髋关节的润滑具有重要作用。那些主要患有关节相关疾病的人更喜欢尝试注射滑膜而不是全髋关节置换术 (THR)。然而，新陈代谢过程对注射的滑膜的影响能够减少假体的寿命。在这项研究中，研究了可注射的热敏琼脂糖水凝胶作为透明质酸的载体，以延长人工髋关节的使用寿命。实验证据揭示了 HA 的生物活性、优异的粘弹性和天然的无定形网络结构。这种材料与大分子琼脂糖相结合，能够形成三维聚合物网络，用于分离轴承的相邻表面并改善润滑，摩擦系数降低 30% 以上。设计的聚合物网络的机械和流变特性在润滑剂累积持续释放中的作用已得到广泛研究。当前工作的新颖性提供了对人工髋关节长期润滑的调查。