Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the major cause of dementia in older people. Here, we report the derivation of human induced pluripotent stem cells (iPSCs) from an AD patient at age of 80 who has the APOE ε4/ε4 genotype and is resilient to cognitive decline for 10 years. The iPSCs reprogrammed from the blood cells of this patient by transient expression of pluripotency genes maintain the ε4/ε4 genotype, are karyotypically normal and display typical iPSC characteristics. Upon differentiation, the iPSCs are able to differentiate into cells of the three germ layers, confirming their pluripotency.

中文翻译：

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适应性阿尔茨海默氏病患者的新型人iPSC系的生成和表征。

阿尔茨海默氏病（AD）是一种进行性神经退行性疾病，是老年人痴呆症的主要原因。在这里，我们报道了来自80岁的AD患者的人诱导多能干细胞（iPSCs）的衍生，该患者具有APOEε4/ε4基因型并且可以抵抗10年的认知衰退。通过多能性基因的瞬时表达从该患者的血细胞中重新编程的iPSC保持ε4/ε4基因型，核型正常，并显示典型的iPSC特征。分化后，iPSC能够分化为三个胚层的细胞，从而确认其多能性。