Orbitofrontal cortex (OFC) is thought to be involved in appropriate processing of rewarding stimuli, and abnormal OFC structure and function has been found in patients with substance use disorders. Atypical patterns of the H-sulcus in the OFC have been primarily identified with schizophrenia, but also with bipolar disorder, both of which are associated with comorbid substance use. Given the high rates of substance use within Axis I psychiatric disorders, it is reasonable to consider how frequencies of OFC patterns in populations with only substance use compare to controls. This information is crucial to disentangle whether atypical frequencies of H-sulcus sulcogyral patterns within psychopathology are associated with the psychiatric or substance use phenotype. Here, we present the first analysis of H-sulcus sulcogyral patterns in a population of adult black men with (n = 84) and without (n = 24) cocaine use disorder (CUD). We find that OFC sulcogyral patterns are not significantly different from the control group, indicating that OFC sulcogyral patterns are not disrupted in patients with CUD. As exploratory analyses, we describe OFC sulcogyral pattern subtypes in this cohort as well as an additional control group (n = 52), in order to add to the growing body of literature on OFC sulcogyral pattern characterization.

中文翻译：

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可卡因使用障碍患者的眶额脑回形态学

眶额皮质 (OFC) 被认为参与了对奖赏刺激的适当处理，并且在物质使用障碍患者中发现了异常的 OFC 结构和功能。OFC 中 H 沟的非典型模式主要与精神分裂症有关，但也与双相情感障碍有关，这两者都与共病物质使用有关。鉴于 Axis I 精神疾病中物质使用率很高，考虑与对照组相比，仅使用物质的人群中 OFC 模式的频率如何是合理的。该信息对于解开精神病理学中 H 沟沟回模式的非典型频率是否与精神病或物质使用表型相关是至关重要的。这里，我们首次分析了患有 (n = 84) 和不患有 (n = 24) 可卡因使用障碍 (CUD) 的成年黑人男性群体中的 H-sulcus sulcogyral 模式。我们发现OFC sulcogyral 模式与对照组没有显着差异，表明CUD 患者OFC sulcogyral 模式没有被破坏。作为探索性分析，我们描述了该队列中的 OFC 硫脑模式亚型以及一个额外的对照组（n = 52），以增加关于 OFC 硫脑模式表征的越来越多的文献。