Macrophages play a pivotal role at all stages of progression of atherosclerosis. However, the macrophage-targeted treatment of atherosclerosis remains elusive. Recently, macrophage-targeted gene therapy via lipid polymer nanoparticles (NPs) to improve the atherosclerotic plaque stability in mice was reported.

中文翻译：

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巨噬细胞靶向基因治疗，以改善动脉粥样硬化斑块的稳定性。

巨噬细胞在动脉粥样硬化进展的所有阶段均起关键作用。但是，以巨噬细胞为靶标的动脉粥样硬化治疗仍然难以捉摸。最近，已经报道了通过脂类聚合物纳米颗粒（NPs）进行巨噬细胞靶向基因治疗以改善小鼠动脉粥样硬化斑块的稳定性。