Due to the genotoxically challenging environments in which they live in, Mycobacteria have a complex DNA damage repair system that is governed by two major DNA damage responses, namely, the LexA/RecA-dependent response and the newly characterized PafBC-mediated response (Müller et al., 2018). The LexA/RecA-dependent response is a well-known bistable response found in different types of bacteria, and the Mycobacteria-specific PafBC-mediated response interacts with and modifies the LexA/RecA-dependent response (Müller et al., 2018). The interaction between the LexA/RecA-dependent response and the PafBC-mediated response has not been characterized mathematically. Our analysis shows that the addition of the PafBC-mediated response sensitizes the overall DNA damage response, effectively lowering the DNA damage rate threshold for activation.

由于分枝杆菌所处的环境具有遗传毒性挑战性环境，因此分枝杆菌具有复杂的DNA损伤修复系统，该系统由两种主要的DNA损伤反应控制，即LexA / RecA依赖性反应和新近表征的PafBC介导的反应（Müller等等（2018）。LexA / RecA依赖性反应是在不同类型的细菌和分枝杆菌中发现的众所周知的双稳态反应特异性的PafBC介导的反应与LexA / RecA依赖性反应相互作用并对其进行修饰（Müller等人，2018）。LexA / RecA依赖的反应和PafBC介导的反应之间的相互作用尚未进行数学表征。我们的分析表明，PafBC介导的应答的添加使总体DNA损伤应答敏感，从而有效降低了激活的DNA损伤率阈值。