Computational Fluid Dynamics (CFD) and Fluid-Structure Interaction (FSI) are currently widely applied in the study of blood flow parameters and their alterations under pathological conditions, which are important indicators for diagnosis of atherosclerosis. In this manuscript, a systematic review of the published literature was conducted, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, on the simulation studies of blood flow in patient-specific geometries of the carotid artery bifurcation. Scopus, PubMed and ScienceDirect databases were used in the literature search, which was completed on the 3rd of August 2020. Forty-nine articles were included after the selection process and were organized in two distinct categories: the CFD studies (36/49 articles), which comprise only the fluid analysis and the FSI studies (13/49 articles), which includes both fluid and Fluid-Structure domain in the analysis. The data of the research works was structured in different categories (Geometry, Viscosity models, Type of Flow, Boundary Conditions, Flow Parameters, Type of Solver and Validation). The aim of this systematic review is to demonstrate the methodology in the modelling, simulation and analysis of carotid blood flow and also identify potential gaps and challenges in this research field.

计算流体动力学（CFD）和流体-结构相互作用（FSI）目前广泛应用于研究血流参数及其在病理条件下的变化，是诊断动脉粥样硬化的重要指标。在这份手稿中，根据系统评价和荟萃分析的首选报告项目的指南，对已发表的文献进行了系统评价，内容涉及颈动脉分叉的患者特定几何形状中的血流模拟研究。文献检索使用了 Scopus、PubMed 和 ScienceDirect 数据库，检索于 2020 年 8 月 3 日完成。49 篇文章在筛选过程后被纳入，分为两个不同的类别：CFD 研究（36/49 篇文章） , 其中仅包括流体分析和 FSI 研究（13/49 篇文章），其中包括分析中的流体和流体结构域。研究工作的数据分为不同类别（几何、粘度模型、流动类型、边界条件、流动参数、求解器类型和验证）。本系统评价的目的是展示颈动脉血流建模、模拟和分析的方法，并确定该研究领域的潜在差距和挑战。