Asperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD). Intestinal dysbiosis is closely linked with metabolic disorders. Our data indicate that ASP achieves these benefits on metabolic homeostasis by reversing HFD-induced gut dysbiosis and by changing gut-derived secondary metabolites and metabolic signaling. Our results indicate that ASP may be used to regulate gut microbiota for the treatment of obesity and type 2 diabetes.

Asperuloside (ASP) 是一种从杜仲叶中提取的环烯醚萜苷。杜仲用于传统中药，具有悠久的健康和长寿功效。在这里，我们研究了 ASP 对肥胖相关代谢紊乱的影响，结果表明 ASP 可以有效降低高脂饮食 (HFD) 喂养小鼠的体重增加、葡萄糖耐受不良和胰岛素抵抗。肠道菌群失调与代谢紊乱密切相关。我们的数据表明，ASP 通过逆转 HFD 引起的肠道菌群失调以及改变肠道衍生的次级代谢物和代谢信号来实现代谢稳态的这些益处。我们的结果表明 ASP 可用于调节肠道微生物群以治疗肥胖和 2 型糖尿病。