Abstract Chitosan has fascinating antibacterial activity, good biodegradation, outstanding biocompatibility, non-toxicity and excellent physical and chemical properties. As a result, chitosan has been widely used in the field of antibacterial. Chitosan and its derivatives show antibacterial activity against fungi, gram-positive bacteria and gram-negative bacteria. In recent years, there have been some reviews about the antibacterial activity of chitosan and its derivatives. This review adds many valuable concerns on the basis of those previous reviews. For example, composite of chitosan and metal, composite of chitosan and metal oxide, etc. This review will systematically analyze various influencing factors of chitosan, so as to clearly summarize the antibacterial mechanism of chitosan. Finally, the challenges and prospects of chitosan-based materials as antimicrobial agents are assessed and commented.

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壳聚糖及其衍生物的抗菌活性及其与细菌的相互作用机制：现状与展望

摘要 壳聚糖具有迷人的抗菌活性、良好的生物降解性、优异的生物相容性、无毒和优良的理化性质。因此，壳聚糖在抗菌领域得到了广泛的应用。壳聚糖及其衍生物对真菌、革兰氏阳性菌和革兰氏阴性菌具有抗菌活性。近年来，关于壳聚糖及其衍生物的抗菌活性已有一些综述。本次审查在先前审查的基础上增加了许多有价值的问题。例如，壳聚糖与金属的复合物、壳聚糖与金属氧化物的复合物等。本综述将系统分析壳​​聚糖的各种影响因素，从而清晰地总结壳聚糖的抗菌机制。最后，