Abstract New biopolymers with rubber-like properties, which are prepared by green method and without using solvents, have been absorbed attention in soft tissue engineering. Residual solvents in biomaterials are as a serious drawback in against of their applications in tissue engineering field. Poly (glycerol sebacate) (PGS) is one of the elastomeric polyesters which is synthesized by poly-condensation of sebacic acid and glycerol utilizing in wide-spread applications. However, PGS needs to gain more in-depth insight into inferior properties to expand its usage in tissue engineering. In this study, a new type of biopolymer-based on Poly(glycerol-sebacate)-co-Poly(caprolactone) (PGS-co-PCL) was synthesized by the melt polycondensation method. In the following, a series of PGS-co-PCL nanocomposites containing various amounts of hydroxyapatite (HA) nanoparticles (0.5, 1 and 1.5 wt.%) were fabricated through the green in-situ polymerization technique. The chemical structure and functional groups of these samples were deciphered by 1H-NMR and FTIR spectroscopy. The morphology was observed via SEM and EDX-Mapping analyses. Also, the dynamic contact angle is used to identify the hydrophilicity effect of copolymerization and nanoparticles. The thermal properties were analyzed by TGA and DSC, as well as dynamic-mechanical properties by DMTA. Furthermore, hydrolytic degradation and cell adhesion are evaluated to find out the biodegradability and biocompatibility performance of PGS-co-PCL based samples in comparison to PGS. Our findings indicated that the addition of Ɛ-caprolactone section into PGS-co-PCL is a practical approach to tune the general features of PGS to make the copolymer to the promising candidate for soft tissue engineering more efficient in the presence of HA in PGS-co-PCL nanocomposites. .

中文翻译：

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聚（甘油-癸二酸酯）-共聚（己内酯）（PGS-co-PCL）及其纳米复合材料作为新型生物材料的设计和表征：软组织工程的有希望的候选者

摘要 通过绿色方法、不使用溶剂制备的具有类橡胶特性的新型生物聚合物在软组织工程领域受到了广泛关注。生物材料中的残留溶剂是阻碍其在组织工程领域应用的严重缺陷。聚（甘油癸二酸酯）（PGS）是一种弹性聚酯，它是由癸二酸和甘油缩聚而成的，应用广泛。然而，PGS 需要更深入地了解劣质特性，以扩大其在组织工程中的应用。在本研究中，采用熔融缩聚法合成了一种基于聚（甘油-癸二酸酯）-共聚（己内酯）（PGS-co-PCL）的新型生物聚合物。在下面的，通过绿色原位聚合技术制造了一系列含有不同量羟基磷灰石 (HA) 纳米颗粒（0.5、1 和 1.5 重量％）的 PGS-co-PCL 纳米复合材料。这些样品的化学结构和官能团通过 1H-NMR 和 FTIR 光谱进行了破译。通过SEM和EDX-Mapping分析观察形态。此外，动态接触角用于识别共聚和纳米粒子的亲水性效应。通过 TGA 和 DSC 分析热性能，并通过 DMTA 分析动态机械性能。此外，对水解降解和细胞粘附进行了评估，以找出与 PGS 相比，基于 PGS-co-PCL 的样品的生物降解性和生物相容性性能。我们的研究结果表明，将Ɛ-己内酯部分添加到 PGS-co-PCL 中是一种实用的方法，可以调整 PGS 的一般特征，使共聚物在 PGS 中存在 HA 的情况下更有效地成为软组织工程的有希望的候选者。共PCL纳米复合材料。.