Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study.,Environment International

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Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study.
Environment International ( IF 11.8 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.envint.2020.106063
Chalana M Sol ₁ , Susana Santos ₁ , Liesbeth Duijts ₁ , Alexandros G Asimakopoulos ₂ , Maria-Pilar Martinez-Moral ₃ , Kurunthachalam Kannan ₄ , Vincent W V Jaddoe ₁ , Leonardo Trasande ₅

Affiliation

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA; Department of Chemistry, The Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Paediatrics, New York University School of Medicine, New York City, NY 10016, USA; Department of Environmental Medicine, New York University School of Medicine, New York City, NY 10016, USA; Department of Population Health, New York University School of Medicine, New York City, NY, USA; New York University Wagner School of Public Service, New York City, NY 10016, USA; New York University College of Global Public Health, New York City, NY 10016, USA.

Background and aims

Fetal exposure to endocrine disruptors such as phthalates and bisphenols may lead to developmental metabolic adaptations. We examined associations of maternal phthalate and bisphenol urine concentrations during pregnancy with lipids, insulin, and glucose concentrations at school age.

Methods

In a population-based, prospective cohort study among 757 mother–child pairs, we measured maternal phthalate and bisphenol urine concentrations in first, second and third trimester of pregnancy. We measured non-fasting lipids, glucose and insulin blood concentrations of their children at a mean age of 9.7 (standard deviation 0.2) years. Analyses were performed for boys and girls separately.

Results

An interquartile range (IQR) higher natural log transformed third trimester maternal urine phthalic acid concentration was associated with a 0.20 (95% confidence interval (CI) 0.07–0.34) standard deviation score (SDS) higher triglycerides concentration among boys. Maternal bisphenol urine concentrations were not associated with non-fasting lipid concentrations during childhood. An IQR higher natural log transformed second trimester maternal high molecular weight phthalates (HMWP) and di-2-ethylhexylphthalate (DEHP) urine concentration were associated with a 0.19 (95% CI 0.31–0.07) respectively 0.18 (95% CI 0.31–0.06) SDS lower glucose concentration among boys. An IQR higher natural log transformed third trimester maternal bisphenol F urine concentration was associated with a 0.22 (95% CI 0.35–0.09) SDS lower non-fasting insulin concentration among boys.

Conclusions

Our results suggest potential persisting sex specific effects of fetal exposure to phthalates and bisphenols on childhood lipid concentrations and glucose metabolism. Future studies are needed for replication and exploring underlying mechanisms.

中文翻译：

胎儿邻苯二甲酸盐和双酚与儿童脂质和葡萄糖代谢。一项基于人群的前瞻性队列研究。

背景和目标

胎儿接触邻苯二甲酸盐和双酚等内分泌干扰物可能会导致发育代谢适应。我们研究了孕期母体邻苯二甲酸盐和双酚尿浓度与学龄期血脂、胰岛素和葡萄糖浓度之间的关联。

方法

在一项对 757 对母子进行的基于人群的前瞻性队列研究中，我们测量了孕早期、中期和晚期孕妇的邻苯二甲酸盐和双酚尿浓度。我们测量了他们孩子平均 9.7 岁（标准差 0.2）岁的非空腹血脂、葡萄糖和胰岛素血浓度。分别对男孩和女孩进行分析。

结果

四分位距 (IQR) 较高的自然对数转换后孕晚期母体尿邻苯二甲酸浓度与 0.20（95% 置信区间 (CI) 0.07–0.34）标准差评分 (SDS) 较高的男孩甘油三酯浓度相关。母亲双酚尿浓度与儿童时期非空腹血脂浓度无关。IQR 较高的自然对数转化孕中期母体高分子量邻苯二甲酸酯 (HMWP) 和邻苯二甲酸二-2-乙基己基酯 (DEHP) 尿液浓度分别与 0.19 (95% CI 0.31-0.07) 0.18 (95% CI 0.31-0.06) 相关SDS 降低男孩的葡萄糖浓度。IQR 较高的自然对数转化孕晚期母体双酚 F 尿浓度与 0.22 (95% CI 0.35–0.