Calcium (Ca²⁺) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca²⁺ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since epigenetic mechanisms are disrupted in all stages of carcinogenesis, and reversibly regulate gene expression, they have been studied by different research groups to understand their role in Ca²⁺ signaling remodeling in cancer cells and the carcinogenic process. In this review, we link Ca²⁺ signaling, cancer, and epigenetics fields to generate a comprehensive landscape of this complex group of diseases.

钙 (Ca ²⁺ ) 信号控制着广泛的细胞过程，包括癌症的标志。Ca ²⁺信号系统包含多种类型的蛋白质，例如受体、通道、泵、交换器、缓冲液和传感器，其中一些在癌细胞中发生突变或表达改变。由于表观遗传机制在致癌的所有阶段都被破坏，并可逆地调节基因表达，因此不同的研究小组对其进行了研究，以了解它们在癌细胞中 Ca ²⁺信号重塑和致癌过程中的作用。在这篇综述中，我们将 Ca ²⁺信号、癌症和表观遗传学领域联系起来，以生成这组复杂疾病的综合图景。