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New insight of red seaweed derived Callophycin A as an alternative strategy to treat drug resistance vaginal candidiasis.
Bioorganic Chemistry ( IF 5.1 ) Pub Date : 2020-09-02 , DOI: 10.1016/j.bioorg.2020.104256
Arumugam Ganeshkumar 1 , Suvaiyarasan Suvaithenamudhan 2 , Elaiyappillai Elanthamilan 3 , Ganesan Arun 1 , Gowrisivam Anbusivam Bharathi Dileepan 3 , Nagarajan Prabhusaran 4 , Rajendran Rajaram 1
Affiliation  

Marine natural products are recognised as one among the major contributors of several important biological functions. The arguments has made to utilization of natural products against different kinds of infectious diseases. In the present study, Callophycin A was successfully prepared and its anti-candidal activity was evaluated through in-vitro and in-vivo methods. The in-vitro results revealed that, Callophycin A significantly inhibits the azole resistant and sensitive C. albicans. Further, in-vivo animal experiments have shown the effective reduction in CFU of C. albicans from its beginning day of the treatment as compared to the disease control group. At the end of Callophycin A administration, there was a decrease in inflammatory response and immune molecules such as IL-6, IL-12, IL-17, IL-22, TNF-α, macrophages, CD4 and CD8 cells were observed. Whereas the animals in the disease control group expressed all the parameters with the elevated level as compared to the control group. There are no hematological abnormalities such as neutropenia, lymphocytosis and eosinophilia was observed in any animal groups except the disease control group. Finally, the evidence based prediction of anti-candidal efficacious of Callophycin A was demonstrated.



中文翻译:

红海藻衍生的愈伤组织A作为治疗耐药性念珠菌病的替代策略的新见解。

海洋天然产物被认为是几种重要生物学功能的主要贡献者之一。有关利用天然产物抗击各种传染病的争论已经提出。在本研究中,成功​​制备了Callophycin A,并通过体外体内方法评估了其抗杀人活性。的体外结果表明,Callophycin甲显著抑制唑抗性和敏感性白色念珠菌。此外,体内动物实验表明有效降低了白色念珠菌的CFU从治疗开始到与疾病对照组相比。在给予Callophycin A结束时,炎症反应降低,并且观察到免疫分子,例如IL-6,IL-12,IL-17,IL-22,TNF-α,巨噬细胞,CD4和CD8细胞。而与对照组相比,疾病对照组中的动物表达的所有参数水平都较高。除疾病对照组外,其他任何动物组均未观察到血液学异常,如中性粒细胞减少,淋巴细胞增多和嗜酸性粒细胞增多。最后,证明了Callophycin A的抗候选杀伤力的基于证据的预测。

更新日期:2020-09-14
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