Abstract

Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation.

Graphic Abstract

中文翻译：

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昆虫医学聚轮藻的新木脂和诺里木脂及其生物活性。

摘要

十新木脂体或norlignans（1 - 10），其包括八个新化合物从整个机构分离多食plancyi玻利瓦尔。它们的结构通过光谱数据鉴定。化合物3，4，8，和9是表示外消旋物通过手性HPLC分析。手性分离，然后进行ECD计算，可以阐明所有对映体的绝对构型。在大鼠肾近端肾小管细胞，人类癌细胞（K562，A549和Huh7），EV71，ROCK2，JAK3，DDR1和凝血中，评估了所有这些新化合物对细胞外基质的生物学特性。

图形摘要