Changes in the absorption spectra of aqueous solutions of modern chlorinated photosensitizing drugs for photodynamic therapy “Revixan” (Areal, Russia) and “Chloderm” (Chloderm, Russia) in the range of 600–700 nm depending on the intensity and time of exposure to LED emission with a wavelength of 656 ± 10 nm have been studied. The parameters of the CIE Lab color model of the “Revixan” water solution image before and after LED exposure have been studied. In the range of 400–900 nm, the changes in the absorption spectra of an aqueous solution of methylene blue with different initial concentrations after exposure to LED emission with a wavelength of 656 ± 10 nm and an intensity of 180 ± 20 mW/cm² have been studied. It has been shown that the effect of LED emission changes the absorption spectra of the studied substances and increases the parameter L (brightness) of the CIE Lab color model for “Revixan”. An increase in the intensity of the LED emission and exposure time causes a decrease in the absorption for “Revixan” and “Chloderm” in the range of 600–700 nm and a shift of the peak of the absorption band lying in this range to the infrared region. The effect of the LED emission on an methylene blue aqueous solution causes a decrease in its absorption in the range of 400–900 nm.

中文翻译：

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研究现代含氯药物对光动力疗法和亚甲基蓝的吸收光谱由于暴露于656±10 nm波长的LED发射而发生的变化

用于光动力疗法的现代氯化光敏药物“ Revixan”（俄罗斯阿雷亚尔）和“ Chloderm”（俄罗斯Chloderm）的水溶液吸收光谱在600-700 nm范围内变化，具体取决于暴露的强度和时间已经研究了波长为656±10 nm的LED发射。研究了LED曝光前后“ Revixan”水溶液图像的CIE Lab颜色模型的参数。在400–900 nm范围内，暴露于波长为656±10 nm且强度为180±20 mW / cm ^2的LED发射后，具有不同初始浓度的亚甲基蓝水溶液的吸收光谱变化已经研究过了。已经表明，LED发射的影响改变了所研究物质的吸收光谱，并增加了“ Revixan”的CIE Lab颜色模型的参数L（亮度）。LED发射强度和曝光时间的增加会导致“ Revixan”和“ Chloderm”在600–700 nm范围内的吸收降低，并且该范围内的吸收带峰会向红外区域。LED发射对亚甲蓝水溶液的影响导致其吸收在400–900 nm范围内下降。