The objective of this study was to evaluate anti-obesity effects of kimchi microbial community (KMC) on obesity and gut microbiota using a high fat diet-induced mouse model compared to effects of a single strain. Administration of KMC decreased body weight, adipose tissue, and liver weight gains. Relative content of Muribaculaceae in the gut of the KMC-treated group was higher than that in the high-fat diet (HFD) group whereas relative contents of Akkermansiaceae, Coriobacteriaceae, and Erysipelotrichaceae were lower in KMC-treated group. Metabolic profile of blood was found to change differently according to the administration of KMC and a single strain of Lactobacillus plantarum. Serum metabolites significantly increased in the HFD group but decreased in the KMC-treated group included arachidic acid, stearic acid, fumaric acid, and glucose, suggesting that the administration of KMC could influence energy metabolism. The main genus in KMC was not detected in guts of mice in KMC-treated group. Since the use of KMC has advantages in terms of safety, it has potential to improve gut microbial community for obese people.

这项研究的目的是使用高脂饮食诱导的小鼠模型评估泡菜微生物群落（KMC）对肥胖和肠道菌群的抗肥胖作用，而不是单一菌株的作用。使用KMC可以减少体重，脂肪组织和肝脏的重量增加。KMC治疗组的肠道中鼠李草科的相对含量高于高脂饮食（HFD）组，而KMC治疗组中的Akkermansiaceae，Coriobacteriaceae和Erysipelotrichaceae的相对含量较低。发现血液的代谢特征会根据施用KMC和植物乳杆菌的一种菌株而有所不同。HFD组的血清代谢物显着增加，而KMC治疗组的血清代谢物减少，包括花生酸，硬脂酸，富马酸和葡萄糖，这表明KMC的使用可能影响能量代谢。在KMC治疗组的小鼠肠中未检测到KMC的主要属。由于使用KMC在安全性方面具有优势，因此有可能改善肥胖人群的肠道微生物群落。