Computed tomography findings of current nonspecific interstitial pneumonia based on the 2013 updated classification of idiopathic interstitial pneumonias: What is a characteristic of previously diagnosed nonspecific interstitial pneumonia excluded from the updated classification.,Japanese Journal of Radiology

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Computed tomography findings of current nonspecific interstitial pneumonia based on the 2013 updated classification of idiopathic interstitial pneumonias: What is a characteristic of previously diagnosed nonspecific interstitial pneumonia excluded from the updated classification.
Japanese Journal of Radiology ( IF 2.1 ) Pub Date : 2020-09-01 , DOI: 10.1007/s11604-020-01036-x
Junya Tominaga ₁ , Tae Iwasawa ₂ , Makiko Murota ₃ , Hiroaki Arakawa ₄ , Takeshi Johkoh ₅ , Yasuhiko Yamano ₆ , Yoshiaki Zaizen ₇ , Kazuya Ichikado ₈ , Mikiko Hashisako ₉ , Yasuhiro Kondoh ₆ , Kensuke Kataoka ₆ , Masaki Okamoto ₁₀ , Kiminori Fujimoto ₁₁ , Junya Fukuoka ₇ ,

Affiliation

Department of Diagnostic Radiology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, 9808574, Japan.
Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Department of Radiology, Faculty of Medicine, Kagawa University, Miki, Japan.
Department of Radiology, Dokkyo Medical University, Mibu, Japan.
Department of Diagnostic Radiology, Kansai Rosai Hospital, Amagasaki, Japan.
Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Japan.
Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan.
Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Department of Anatomic Pathology, Pathological Sciences , Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Department of Radiology and Center for Diagnostic Imaging, Kurume University School of Medicine, Kurume, Japan.

Purpose

To evaluate computed tomography (CT) findings of nonspecific interstitial pneumonia (NSIP) based on the current classification of idiopathic interstitial pneumonias (IIPs) and elucidate a characteristic of previously diagnosed NSIP excluded from the current classification.

Materials and methods

The study included 74 patients with biopsy-proven NSIP (idiopathic NSIP [I-NSIP], 39 patients; NSIP associated with connective tissue disease [CTD-NSIP], 35 patients). Among patients who were compatible with the current classification of IIPs, 29 and 21 were categorized as having current I-NSIP and current CTD-NSIP, respectively. The remaining 24 patients were categorized as having previous I-NSIP or previous CTD-NSIP due to the primary pathologic diagnosis of cellular NSIP or associated findings of acute inflammatory changes. CT findings were evaluated and compared among the four groups.

Results

Current I-NSIP was indicated by ground-glass attenuation and reticulation with traction bronchiectasis/bronchiolectasis in predominantly peribronchovascular areas of the lower lung zone. The previous I-NSIP group tended to show broader airspace consolidation than the current I-NSIP group (p = 0.068). The previous CTD-NSIP group showed significantly broader airspace consolidation than the current I-NSIP group (p = 0.035).

Conclusion

Broad airspace consolidation is a characteristic of previously diagnosed CTD-NSIP excluded from the current classification of IIPs.

中文翻译：

基于2013年特发性间质性肺炎分类的当前非特异性间质性肺炎的计算机体层摄影检查结果：从更新的分类中排除的先前诊断出的非特异性间质性肺炎的特征是什么。

目的

为了评估基于特发性间质性肺炎（IIP）的当前分类的非特异性间质性肺炎（NSIP）的计算机断层扫描（CT）发现，并阐明从当前分类中排除的先前诊断出的NSIP的特征。

材料和方法

该研究包括74例经活检证实的NSIP患者（特发性NSIP [I-NSIP] 39例；与结缔组织病相关的NSIP [CTD-NSIP] 35例）。在符合当前IIP分类标准的患者中，分别将29名和21名分类为具有当前I-NSIP和当前CTD-NSIP。其余24例患者由于细胞NSIP的主要病理诊断或相关的急性炎症改变而被归类为既往I-NSIP或CTD-NSIP。在四组中对CT表现进行评估和比较。