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Gut microbial characteristics of adult patients with allergy rhinitis.
Microbial Cell Factories ( IF 6.4 ) Pub Date : 2020-09-01 , DOI: 10.1186/s12934-020-01430-0
Libing Zhu 1 , Feng Xu 2 , Wenrong Wan 2 , Bin Yu 3 , Lin Tang 3 , Yimin Yang 4 , Yanling Du 5 , Zhangran Chen 6, 7, 8 , Hongzhi Xu 6, 7, 8
Affiliation  

Although recent studies have indicated that intestinal microbiota dweller are involved in the pathogenesis of allergy rhinitis (AR), the influence of gut microbiota on AR adult has not been fully elucidated yet. Hence, we carried out this study to uncover the distinctive bacterial taxa that differentiate allergy rhinitis patients from healthy individuals. Feces samples from thirty three AR patients and thirty one healthy individuals were analyzed by 16S rRNA gene sequencing. Results showed that the bacterial diversity in AR group was significantly higher than that of the non-AR group. Bacterial communities between AR and non-AR group were significantly differentiated as revealed by Principal coordinates analysis (PCoA) and the variation within non-AR were higher than that of the counterpart. Firmicutes, Fusobacteria, Actinobacteria, Cyanobacteria and Chloroflexi were the significantly differed phyla taxa and the top significantly distinguished bacterial genus included Prevotella_9, Phascolarctobacterium, Roseburia, Megamonas, Alistipes, Lachnoclostridium and Fusobacterium. The higher network complexity in AR group were dominated by taxa belonging to Firmicutes. The predicted function, alpha linolenic acid metabolism and bacterial invasion of epithelial cells pathway were higher in non-AR group while gonadotropin-releasing hormone (GnRH) signaling pathway, Fc γ-R mediated phagocytosis and endocytosis were higher in AR patients. Although the bacterial diversity between moderate and severe AR patients showed no significant difference, the significant correlation between featured genus and total nasal symptom score or rhinoconjunctivitis quality of life questionnaire, such as Butyricicoccus and Eisenbergiella, revealed the potential to intervene the AR status by means of gut microbiota. In conclusion, patients with allergy rhinitis had distinguished gut microbiota characteritics in comparison with healthy controls. The results suggest that gut microbiota might play crucial roles in influencing the course and different symptoms of AR. Trial registration ChiCTR, ChiCTR1900028613. Registered 29 December 2019, https://www.chictr.org.cn/showproj.aspx?proj=47650 .

中文翻译:

成人过敏性鼻炎患者肠道菌群特征。

尽管最近的研究表明肠道菌群居民与变应性鼻炎(AR)的发病机理有关,但尚未完全阐明肠道菌群对AR成人的影响。因此,我们进行了这项研究,以发现区分过敏性鼻炎患者与健康个体的独特细菌类群。通过16S rRNA基因测序分析了33例AR患者和31例健康个体的粪便样本。结果表明,AR组的细菌多样性明显高于非AR组。通过主坐标分析(PCoA)揭示,AR和非AR组之间的细菌群落具有显着差异,并且非AR内的细菌变异高于对应组。Firmicutes,Fusobacteria,Actinobacteria,蓝细菌和绿弯曲菌是明显不同的类群,而最显着的细菌属包括Prevotella_9,杆菌属,玫瑰菌,大摩纳哥,阿利司提氏,梭菌和梭菌。AR组中较高的网络复杂性主要是Firmicutes的分类单元。非AR组的预测功能,α亚麻酸代谢和上皮细胞的细菌入侵较高,而AR患者的促性腺激素释放激素(GnRH)信号通路,Fcγ-R介导的吞噬作用和内吞作用较高。尽管中度和重度AR患者之间的细菌多样性无显着差异,但特征性属与总鼻症状评分或鼻结膜炎生活质量问卷之间存在显着相关性,如Butyricicoccus和Eisenbergiella,揭示了通过肠道菌群干预AR状态的潜力。总之,与健康对照组相比,过敏性鼻炎患者具有明显的肠道菌群特征。结果表明,肠道菌群可能在影响AR的病程和不同症状中起关键作用。试用注册ChiCTR,ChiCTR1900028613。注册于2019年12月29日,https://www.chictr.org.cn/showproj.aspx?proj=47650 结果表明,肠道菌群可能在影响AR的病程和不同症状中起关键作用。试用注册ChiCTR,ChiCTR1900028613。注册于2019年12月29日,https://www.chictr.org.cn/showproj.aspx?proj=47650 结果表明,肠道菌群可能在影响AR的病程和不同症状中起关键作用。试用注册ChiCTR,ChiCTR1900028613。注册于2019年12月29日,https://www.chictr.org.cn/showproj.aspx?proj=47650
更新日期:2020-09-01
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