Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.

中文翻译：

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基于肝素的可注射微载体，可控制将白介素13递送至大脑。

白细胞介素13（IL-13）驱动髓样来源的细胞趋向于更抗发炎的表型，但向大脑的递送仍然存在问题。在这里，我们显示基于肝素的冷冻凝胶微载体加载大量的IL-13，缓慢释放它。纹状体内注射负载的微载体导致髓样细胞中ARG1的局部上调，从而促进大脑中的再生性免疫调节。