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Multi-layer 3D chirality: its enantioselective synthesis and aggregation-induced emission
National Science Review ( IF 20.6 ) Pub Date : 2020-04-02 , DOI: 10.1093/nsr/nwaa205 Junliang Zhang 1 , László Kürti 2
National Science Review ( IF 20.6 ) Pub Date : 2020-04-02 , DOI: 10.1093/nsr/nwaa205 Junliang Zhang 1 , László Kürti 2
Affiliation
Chirality has been extensively studied in interdisciplinary fields for almost two centuries since its ubiquity was discovered by Louis Pasteur in 1848, when he successfully separated a pair of enantiomers. Indeed, chirality is present at all levels in nature—in the form of subatomic particles, macromolecules such as proteins and DNA, microscopic living organisms such as helical bacteria and even in the form of macroscopic objects such as sea shells and spiral galaxies. It is undeniable that the concept of chirality and the field of stereochemistry, which studies the three-dimensional (3D) structure and relationships of molecules, has had a monumental impact on chemical, biomedical and material sciences [1]. Not surprisingly, the design and synthesis of an ever-increasing number of small-molecule pharmaceuticals as well as optical materials heavily depend on our deep understanding and exploitation of molecular chirality. In chemistry, chirality is divided into point/central, spiro, axial, helical/planar as well as the multi-layer versions of helical/planar chirality [2]. With the exception of multilayer chirality all the other types exist widely in nature.
中文翻译:
多层 3D 手性:其对映选择性合成和聚集诱导发射
自从路易斯巴斯德于 1848 年成功分离一对对映异构体后发现手性无处不在以来,手性在跨学科领域已被广泛研究近两个世纪。事实上,手性存在于自然界的各个层面——以亚原子粒子、蛋白质和 DNA 等大分子、螺旋细菌等微观生物体的形式,甚至以贝壳和螺旋星系等宏观物体的形式存在。不可否认,手性的概念和立体化学领域研究分子的三维(3D)结构和关系,对化学、生物医学和材料科学产生了巨大的影响。1]。毫不奇怪,越来越多的小分子药物和光学材料的设计和合成在很大程度上取决于我们对分子手性的深入理解和开发。在化学中,手性分为点/中心、螺旋、轴、螺旋/平面以及螺旋/平面手性的多层版本。2]。除了多层手性之外,所有其他类型都广泛存在于自然界中。
更新日期:2020-04-02
中文翻译:
多层 3D 手性:其对映选择性合成和聚集诱导发射
自从路易斯巴斯德于 1848 年成功分离一对对映异构体后发现手性无处不在以来,手性在跨学科领域已被广泛研究近两个世纪。事实上,手性存在于自然界的各个层面——以亚原子粒子、蛋白质和 DNA 等大分子、螺旋细菌等微观生物体的形式,甚至以贝壳和螺旋星系等宏观物体的形式存在。不可否认,手性的概念和立体化学领域研究分子的三维(3D)结构和关系,对化学、生物医学和材料科学产生了巨大的影响。1]。毫不奇怪,越来越多的小分子药物和光学材料的设计和合成在很大程度上取决于我们对分子手性的深入理解和开发。在化学中,手性分为点/中心、螺旋、轴、螺旋/平面以及螺旋/平面手性的多层版本。2]。除了多层手性之外,所有其他类型都广泛存在于自然界中。