The current aggregation-induced emission luminogens (AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with ‘always-on’ fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence. Herein, we report an unprecedented ‘amphiphilic AIEgen’ sensor QM-SO₃-ER based on the AIE building block of quinoline-malononitrile (QM). The introduced hydrophilic sulfonate group can well control the specific solubility in a hydrophilic system with desirable initial ‘fluorescence-off’ state. Moreover, the incorporated p-toluenesulfonamide group plays two roles: enhancing the lipophilic dispersity, and behaving as binding receptor to the adenosine triphosphate (ATP)-sensitive potassium (K_ATP) on the endoplasmic reticulum (ER) membrane to generate the docking assay confinement effect with targetable AIE signal. The amphiphilic AIEgen has for the first time settled down the predicament of unexpected ‘always-on’ fluorescence in the aqueous system and the untargetable aggregation signal in the lipophilic organelle before binding to ER, thus successfully overcoming the bottleneck of AIEgens' targetability.

中文翻译：

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通过 ATP 敏感钾 (KATP) 的特异性相互作用，用两亲性 AIE 活性传感器捕获内质网

当前的聚集诱导发射发光体 (AIEgens) 有时会因亲水生物系统中的不合需要的聚集而导致靶向选择性较差，“永远在线”的荧光或亲脂细胞器中的非特异性聚集具有过早激活的荧光。在此，我们报告了一种前所未有的“两亲AIEgen”传感器 QM-SO ₃ -ER，其基于​​喹啉-丙二腈 (QM) 的 AIE 构建块。引入的亲水性磺酸盐基团可以很好地控制在亲水体系中的特定溶解度，并具有理想的初始“荧光关闭”状态。此外，纳入的p-甲苯磺酰胺基团有两个作用：增强亲脂性分散性，并作为内质网 (ER) 膜上三磷酸腺苷 (ATP) 敏感钾 (K _ATP ) 的结合受体，产生具有可靶向 AIE 信号的对接试验限制效应. 所述两亲性AIEgen具有用于在第一时间定居下来的困境意外“永远在线”在水体系荧光和结合ER，从而成功地克服AIEgens'靶向性的瓶颈之前在所述亲脂性细胞器不能被指定聚合信号。