Identification upon admission of a group of patients with severe traumatic injury presenting with a higher risk of death is crucial in designing personalized treatment strategies [1]. However, there are as yet limited biomarkers for the prediction of mortality in patients with traumatic injury. 12(S)-Hydroxyeicosatetraenoic acid (12(S)-HETE), as a classic metabolite of arachidonic acid, was suggested to be a potential biomarker in brain injury [2] or subarachnoid hemorrhage [3]. Here we report on a prospective observational analysis of the biomarker 12(S)-HETE in plasma samples collected from 76 adult patients with traumatic injury admitted to the emergency department (ED) (within the first 48 h post-trauma) and 25 healthy adults from two tertiary teaching hospitals in Chongqing between October 2018 and October 2019.

中文翻译：

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评估血浆12（S）-羟基二十二碳四烯酸作为一种生物标志物，以预测患有严重创伤的成人的死亡率。

入组一组具有较高死亡风险的严重外伤的患者的识别对于设计个性化治疗策略至关重要[1]。然而，目前尚缺乏用于预测创伤性损伤患者死亡率的生物标志物。作为花生四烯酸的经典代谢产物的12（S）-羟基二十碳四烯酸（12（S）-HETE）被认为是脑损伤的潜在生物标志物[2]或蛛网膜下腔出血[3]。在这里，我们报告了对从急诊科（ED）（创伤后第一个48小时内）入院的76名成年创伤性创伤患者和25名健康成年人采集的血浆样品中生物标志物12（S）-HETE进行的前瞻性观察分析于2018年10月至2019年10月在重庆的两家三级教学医院接受治疗。