Ynamides are electron-rich heteroatom-substituted alkynes with a C–C triple bond directly attached to the amide group. Importantly, this amide group is able to impose an electronic bias, thus resulting in the highly regioselective attack of this polarized alkyne by a large variety of nucleophiles. Over the past two decades, catalytic reactions of ynamides have experienced dramatic developments, especially those catalyzed by transition metals. As a result, ynamides have been widely applied to the rapid and efficient assembly of versatile structurally complex N-containing molecules, especially in an atom-economic and stereoselective way.

中文翻译：

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酰胺的过渡金属催化串联反应，用于合成不同的N-杂环。

酰胺是富含电子的杂原子取代的炔烃，具有直接与酰胺基团相连的CC三键。重要的是，该酰胺基能够施加电子偏压，从而导致该极化炔烃被多种亲核试剂高度区域选择性地攻击。在过去的二十年中，乙酰胺的催化反应经历了引人注目的发展，特别是那些由过渡金属催化的反应。结果，尤其是以原子经济和立体选择性的方式，乙酰胺已被广泛应用于快速有效地组装通用的结构复杂的含氮分子。