Abstract Rhodanine structural scaffolds are an important class of sulfur-containing heterocycles with a broad spectrum of applications in medicinal chemistry. Highly functionalized piperidine scaffolds have shown profound impact in drug discovery research owing to its important bioactivity. The green and high-yielding synthesis of rhodanine structural scaffolds from readily available materials remains is a hot topic research for the synthetic chemistry community. In this review, we discuss the recent various synthetic procedures reported in the literature for the synthesis of rhodanine structural scaffolds. Graphical Abstract Examples of biologically active rhodanine derivatives.

中文翻译：

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罗丹宁支架的合成路线

摘要 罗丹宁结构支架是一类重要的含硫杂环化合物，在药物化学中有广泛的应用。由于其重要的生物活性，高度官能化的哌啶支架在药物发现研究中显示出深远的影响。从现成的材料中绿色、高产地合成罗丹宁结构支架是合成化学界的一个热门研究课题。在这篇综述中，我们讨论了最近文献中报道的用于合成罗丹宁结构支架的各种合成程序。生物活性罗丹宁衍生物的图形摘要实例。