Chronic stress exposure is associated with impaired cognitive function; however, the underlying mechanism is not yet clear. This study investigated the association between perceived chronic stress and anticipatory processing, measured by event-related potentials, and the moderating role of resilience on this relationship in healthy adults. Fifty-nine healthy volunteers (22.52 ± 1.75 years) underwent a continuous performance test, and anticipatory processing was indexed with the contingent negative variation (CNV) of event-related potentials, the Cohen Perceived Stress Scale, and the Connor-Davidson Resilience Scale. The results showed that greater reports of perceived chronic stress were associated with more negative early CNVs; however, there was no significant relationship between perceived chronic stress and behavioral performance on the continuous performance test. More importantly, the relationship between perceived chronic stress and early CNV was moderated by resilience as the association between the Cohen Perceived Stress Scale score and early CNV amplitude was significant for low and average levels of resilience. These results not only suggest that chronic stress may lead to decreased cognitive efficiency in cortical anticipatory activity, but also underscore the role of resilience as a key protective factor in decreased cognitive efficiency.

慢性应激暴露与认知功能受损有关。但是，其潜在机制尚不清楚。这项研究调查了感知的慢性压力与预期事件之间的关联，该关联由事件相关的电位来衡量，并且在健康成人中，韧性对这种关系的调节作用。59名健康志愿者（22.52±1.75岁）接受了持续的性能测试，并用事件相关电位的或有负性变异（CNV），Cohen感知压力量表和Connor-Davidson适应力量表对预期处理进行了索引。结果表明，更多的关于慢性压力的报道与早期CNV阴性有关。然而，在持续表现测试中，感知到的慢性压力与行为表现之间没有显着关系。更重要的是，由于低和平均恢复力水平，Cohen感知压力量表评分与早期CNV幅度之间的关联非常重要，因此通过弹性可以缓解慢性压力与早期CNV之间的关系。这些结果不仅表明慢性应激可能导致皮质预期活动的认知效率下降，而且强调了韧性是降低认知效率的关键保护因素的作用。由于低和平均弹性水平的Cohen感知压力量表评分与早期CNV振幅之间的相关性很显着，因此可以通过适应力来缓解感知的慢性压力与早期CNV之间的关系。这些结果不仅表明慢性应激可能导致皮质预期活动的认知效率下降，而且强调了韧性是降低认知效率的关键保护因素的作用。由于低和平均弹性水平的Cohen感知压力量表评分与早期CNV振幅之间的相关性很显着，因此可以通过适应力来缓解感知的慢性压力与早期CNV之间的关系。这些结果不仅表明慢性应激可能导致皮质预期活动的认知效率降低，而且强调了韧性是降低认知效率的关键保护因素的作用。