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Protecting Connections from Synapse Elimination
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.tins.2020.08.005
Gabrielle L Sell 1 , A Kimberley McAllister 1
Affiliation  

A recent paper by Cong et al. provides exciting evidence that neurons contain proteins that protect synapses from complement-mediated synapse elimination. SRPX2 binds C1q and blocks microglial synapse engulfment. The findings point at SRPX2, and potentially other related sushi domain proteins, as possible targets for therapies for neurodevelopmental and neurodegenerative disorders.

中文翻译:

保护连接免受突触消除

Cong 等人最近发表的一篇论文。提供了令人兴奋的证据,证明神经元含有保护突触免受补体介导的突触消除的蛋白质。SRPX2 结合 C1q 并阻断小胶质细胞突触吞噬。研究结果指向 SRPX2 和其他可能相关的 sushi 结构域蛋白,作为神经发育和神经退行性疾病治疗的可能靶点。
更新日期:2020-11-01
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