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BFRF1 protein is involved in EBV-mediated autophagy manipulation.
Microbes and Infection ( IF 5.8 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.micinf.2020.08.002
Roberta Gonnella 1 , Marzia Dimarco 1 , Giuseppina A Farina 2 , Roberta Santarelli 1 , Sandro Valia 3 , Alberto Faggioni 1 , Antonio Angeloni 1 , Mara Cirone 1 , Antonella Farina 4
Affiliation  

Viral egress and autophagy are two mechanisms that seem to be strictly connected in Herpesviruses’s biology. Several data suggest that the autophagic machinery facilitates the egress of viral capsids and thus the production of new infectious particles. In the Herpesvirus family, viral nuclear egress is controlled and organized by a well conserved group of proteins named Nuclear Egress Complex (NEC). In the case of EBV, NEC is composed by BFRF1 and BFLF2 proteins, although the alterations of the nuclear host cell architecture are mainly driven by BFRF1, a multifunctional viral protein anchored to the inner nuclear membrane of the host cell. BFRF1 shares a peculiar distribution with several nuclear components and with them it strictly interacts. In this study, we investigated the possible role of BFRF1 in manipulating autophagy, pathway that possibly originates from nucleus, regulating the interplay between autophagy and viral egress.



中文翻译:

BFRF1蛋白参与EBV介导的自噬操纵。

病毒的排出和自噬是疱疹病毒生物学中似乎严格联系的两种机制。一些数据表明自噬机制促进了病毒衣壳的排出,从而促进了新的传染性颗粒的产生。在疱疹病毒家族中,病毒核外排是由一组保守性强的蛋白质控制和组织的,这些蛋白质称为核外排复合物(NEC)。对于EBV,NEC由BFRF1和BFLF2蛋白组成,尽管核宿主细胞结构的改变主要由BFRF1驱动,BFRF1是一种锚定在宿主细胞内核膜上的多功能病毒蛋白。BFRF1与几个核成分共享独特的分布,并且与它们严格相互作用。在这项研究中,我们研究了BFRF1在操纵自噬中的可能作用,

更新日期:2020-09-01
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