Advances in reading, writing, and editing DNA are providing unprecedented insights into the complexity of immunological systems. This combination of systems and synthetic biology methods is enabling the quantitative and precise understanding of molecular recognition in adaptive immunity, thus providing a framework for reprogramming immune responses for translational medicine. In this review, we will highlight state-of-the-art methods such as immune repertoire sequencing, immunoinformatics, and immunogenomic engineering and their application toward adaptive immunity. We showcase novel and interdisciplinary approaches that have the promise of transforming the design and breadth of molecular and cellular immunotherapies.

读，写和编辑DNA的进步为免疫系统的复杂性提供了空前的见识。系统与合成生物学方法的这种结合使得能够定量和精确地了解适应性免疫中的分子识别，从而为重编程转化医学的免疫应答提供了框架。在这篇综述中，我们将重点介绍最先进的方法，例如免疫库测序，免疫信息学和免疫基因组工程及其在适应性免疫中的应用。我们展示了新颖且跨学科的方法，有望改变分子和细胞免疫疗法的设计和广度。