Abstract The binuclear [Pd2(κ2-ptt)4] (1) and mixed ligand complexes of the type [Pd(κ1-S-ptt)2(κ2-diamine)] (2-4) (Hptt is 1-phenyl-1H-tetrazole-5-thiol), diamine; ethylene diamine (en), 1,10-phenanthroline (Phen) or 2,2'-bipyridyl (Bipy) as co-ligands have been synthesized. The obtained complexes were characterized by elemental analysis, 1H-, 13C-{1H} NMR, molar conductivity, UV-Vis and IR spectroscopy. In complex 1 the ptt anion coordinated as a bridging bidentate via the thione sulfur atom and deprotonated nitrogen atom of the heterocyclic ring to afford a dimeric complex. Whereas in 2-4 the ptt bonded as a monodentate through the thiolato sulfur atom, while the diamine ligands are coordinated as bidentate chelates to afford a square planner arrangement around the Pd(II) center. The anti-fungal activity of the prepared complexes (1–4) was tested against two fungi types (Candida albicans, and Aspergillus niger). All the complexes showed moderate activity compared to standard Fluconazole. Moreover, the anti-cancer activity of complexes (2-4) were examined against ovarian and breast cancer cells. Cell viability assays show that complexes (2-4) are promising anti-tumor in vitro.

中文翻译：

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新型钯 (II) 1-苯基-1H-四唑-5-硫醇配合物的抗癌和抗真菌评价

摘要 双核 [Pd2(κ2-ptt)4] (1) 和 [Pd(κ1-S-ptt)2(κ2-二胺)] (2-4) 型混合配体复合物（Hptt 是 1-苯基- 1H-四唑-5-硫醇），二胺；已合成乙二胺 (en)、1,10-菲咯啉 (Phen) 或 2,2'-联吡啶 (Bipy) 作为共配体。所得配合物通过元素分析、1H-、13C-{1H}NMR、摩尔电导率、UV-Vis和IR光谱表征。在配合物 1 中，ptt 阴离子通过硫酮硫原子和杂环的去质子化氮原子配位为桥接双齿，以提供二聚体配合物。而在 2-4 中，ptt 通过硫醇合硫原子以单齿形式键合，而二胺配体以双齿螯合物的形式配位，以提供围绕 Pd(II) 中心的方形平面排列。针对两种真菌类型（白色念珠菌和黑曲霉）测试了制备的复合物 (1-4) 的抗真菌活性。与标准氟康唑相比，所有复合物均表现出中等活性。此外，还检测了复合物 (2-4) 对卵巢和乳腺癌细胞的抗癌活性。细胞活力测定表明复合物 (2-4) 在体外具有良好的抗肿瘤作用。