The aim of this research was to test the ability of cultures of edible fungi to biotransform three bicyclic halolactones. The substrates (2-chloro-, 2-bromo- and 2-iodo-4,4,6,7-tetramethyl-9-oxabicyclo[4.3.0]nonan-8-one) received by means of synthesis were transformed by oyster mushroom Pleurotus ostreatus and edible mushrooms of the genus Armillaria mellea, Marasmius scorodonius and Laetiporus sulfureus. The substrates were converted to hydroxyl derivatives only by the cultures of oyster mushroom. Out of seven strains of Pleurotus ostreatus - three were capable of hydroxylation of all substrates with the most effective conversion of chlorolactone. Bromo- and iodolactone were transformed to a small extent. Four new chloro-hydroxylactones were obtained as biotransformation products. The structures of substrates and products were established on the basis of spectroscopic data. Studies of antimicrobial activity performed on reference strains of pathogenic microorganisms showed that halolactones caused complete inhibition of growth of A. alternata and F. linii strains. On the other hand, chloro-hydroxylactones were able to completely inhibit the growth of A. alternata and F. linii strains and also C. albicans strain.

这项研究的目的是测试食用菌培养物对三种双环卤代内酯进行生物转化的能力。用牡蛎转化合成的底物（2-氯-，2-溴-和2-碘-4,4,6,7-四甲基-9-氧杂环[4.3.0] nonan-8-one）食用菌平菇和属食用菌蜜环菌，皮scorodonius的和硫色绚孔菌sulfureus。仅通过牡蛎蘑菇的培养将底物转化为羟基衍生物。在平菇中的七种菌株中-三种能够以最有效的氯内酯转化率将所有底物羟基化。溴和碘内酯在很小的程度上转化了。获得了四种新的氯代羟基内酯作为生物转化产物。基板和产品的结构是根据光谱数据建立的。抗菌活性的研究的病原微生物显示halolactones引起的生长的完全抑制的参照菌株进行格孢和F. linii菌株。在另一方面，氯hydroxylactones能够完全抑制生长链格孢和F. linii菌株和也白色念珠菌菌株。