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A versatile and low-cost chip-to-world interface: Enabling ICP-MS characterization of isotachophoretically separated lanthanides on a microfluidic device
Analytica Chimica Acta ( IF 6.2 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.aca.2020.08.049
Hope Lackey , Danny Bottenus , Martin Liezers , Steve Shen , Shirmir Branch , Jeff Katalenich , Amanda Lines

Microfluidics offer novel and state-of-the-art pathways to process materials. Microfluidic systems drastically reduce timeframes and costs associated with traditional lab-scale efforts in the area of analytical sample preparations. The challenge arises in effectively connecting microfluidics to off-chip analysis tools to accurately characterize samples after treatment on-chip. Fabrication of a chip-to-world connection includes one end of a fused silica capillary interfaced to the outlet of a microfluidic device (MFD). The other end of the capillary is connected to a commercially available CEI-100 interface that passes samples into an inductively coupled plasma mass spectrometer (ICP-MS). This coupling creates an inexpensive and simple chip-to-world connection that enables on-chip and off-chip methods of analyzing the separation of rare earth elements. Specifically, this is demonstrated by utilizing isotachophoresis (ITP) on a microfluidic chip to separate up to 14 lanthanides from a homogenous sample into elementally pure bands. The separated analyte zones are successfully transferred across a 7 nL void volume at the microchip-capillary junction, such that separation resolution is maintained and even increased through the interface and into the ICP-MS, where the elemental composition of the sample is analyzed. Lanthanide samples of varying composition are detected using ICP-MS, demonstrating this versatile and cost-effective approach, which maintains the separation quality achieved on the MFD. This simple connection enables fast, low-cost sample preparation immediately prior to injection into an ICP-MS or other analytical instrument.

中文翻译:

通用且低成本的芯片到世界接口:在微流体设备上实现等速分离镧系元素的 ICP-MS 表征

微流体技术提供了处理材料的新颖和最先进的途径。微流体系统大大减少了与分析样品制备领域的传统实验室规模工作相关的时间框架和成本。在有效地将微流体连接到芯片外分析工具以准确表征芯片上处理后的样品时,挑战就出现了。芯片到世界连接的制造包括连接到微流体装置 (MFD) 出口的熔融石英毛细管的一端。毛细管的另一端连接到商用 CEI-100 接口,该接口将样品传送到电感耦合等离子体质谱仪 (ICP-MS)。这种耦合创建了一种廉价且简单的芯片到世界的连接,使分析稀土元素分离的芯片上和芯片外方法成为可能。具体来说,这是通过利用微流体芯片上的等速电泳 (ITP) 将多达 14 种镧系元素从同质样品中分离成元素纯带来证明的。分离的分析物区域在微芯片 - 毛细管连接处成功转移到 7 nL 的空隙体积,从而保持分离分辨率,甚至通过接口提高分离分辨率,进入 ICP-MS,在那里分析样品的元素组成。使用 ICP-MS 检测不同成分的镧系元素样品,展示了这种通用且经济高效的方法,可保持 MFD 上实现的分离质量。这种简单的连接可以快速、
更新日期:2020-11-01
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