Drug nanodelivery systems (DNDSs) are fascinated cargos to achieve outstanding therapeutic results of various drugs or natural bioactive compounds owing to their unique structures. The efficiency of several pharmaceutical drugs or natural bioactive ingredients is restricted because of their week bioavailability, poor bioaccessibility and pharmacokinetics after orally pathways. In order to handle such constraints, usage of native/natural polysaccharides (NPLS) in fabrication of DNDSs has gained more popularity in the arena of nanotechnology for controlled drug delivery to enhance safety, biocompatibility, better retention time, bioavailability, lower toxicity and enhanced permeability. The main commonly used NPLS in nanoencapsulation systems include chitosan, pectin, alginates, cellulose, starches, and gums recognized as potential materials for fabrication of cargos. Herein, this review is centered on different polysaccharide-based nanocarriers including nanoemulsions, nanohydrogels, nanoliposomes, nanoparticles and nanofibers, which have already served as encouraging candidates for entrapment of therapeutic drugs as well as for their sustained controlled release. Furthermore, the current article explicitly offers comprehensive details regarding application of NPLS-based nanocarriers encapsulating several drugs intended for the handling of numerous disorders, including diabetes, cancer, HIV, malaria, cardiovascular and respiratory as well as skin diseases.

药物纳米递送系统（DNDS）是一种令人着迷的货物，由于其独特的结构，可实现各种药物或天然生物活性化合物的出色治疗效果。几种药物或天然生物活性成分的效率受到限制，因为它们的每周生物利用度，不良的生物利用度和口服途径后的药代动力学。为了应对这些限制，在DNDS制备中使用天然/天然多糖（NPLS）在纳米技术领域中获得了越来越多的控制药物输送，以增强安全性，生物相容性，更长的保留时间，生物利用度，更低的毒性和通透性。纳米封装系统中常用的主要NPLS包括壳聚糖，果胶，藻酸盐，纤维素，淀粉，和被认为是制造货物的潜在材料的口香糖。本文中，本综述集中在不同的基于多糖的纳米载体上，包括纳米乳剂，纳米水凝胶，纳米脂质体，纳米颗粒和纳米纤维，它们已经成为诱捕治疗药物及其持续控释的候选药物。此外，当前文章明确提供了有关基于NPLS的纳米载体的应用的全面细节，该纳米载体封装了用于治疗多种疾病的多种药物，包括糖尿病，癌症，HIV，疟疾，心血管疾病和呼吸道疾病以及皮肤病。它们已经成为诱捕治疗药物及其持续控释的候选药物。此外，当前文章明确提供了有关基于NPLS的纳米载体的应用的全面细节，该纳米载体封装了用于治疗多种疾病的多种药物，包括糖尿病，癌症，HIV，疟疾，心血管疾病和呼吸道疾病以及皮肤病。它们已经成为诱捕治疗药物及其持续控释的候选药物。此外，当前文章明确提供了有关基于NPLS的纳米载体的应用的全面细节，该纳米载体封装了用于治疗多种疾病的多种药物，包括糖尿病，癌症，HIV，疟疾，心血管疾病和呼吸道疾病以及皮肤病。