Here, we show the dependence of intracellular calcium kinetics and the duration of the action potential of cardiomyocytes on an animal’s age in multicellular preparations of the myocardium of the left and right ventricles of healthy control rats and rats with inherent arterial hypertension. In the myocardium samples from control or hypertensive rats the kinetics of the decline of free intracellular calcium slows with age and the differences between the groups become minimal. The short-term deceleration phase of intracellular calcium decline, which is clearly seen in the right ventricle of young hypertensive rats, is smoothed. The duration of the repolarization phase in cardiomyocytes of both ventricles of rats of the control and hypertensive groups shortens; however, it is always higher in the right ventricle samples of control rats with respect to that in the myocardium of hypertensive rats. Here we show the age-related changes in some features of the electromechanical coupling in the myocardium of rats with inherited arterial hypertension for the first time. These experimental data demonstrate the development of spontaneous hypertrophy probably induced by activation of the renin–angiotensin system.

中文翻译：

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自发性高血压ISIAH大鼠心室心肌细胞内钙动力学及动作电位

在这里，我们展示了细胞内钙动力学和心肌细胞动作电位持续时间对动物年龄的依赖性，在健康对照大鼠和患有先天性动脉高血压的大鼠的左心室和右心室心肌的多细胞制剂中。在来自对照或高血压大鼠的心肌样本中，游离细胞内钙的下降动力学随着年龄的增长而减慢，并且各组之间的差异变得最小。在年轻高血压大鼠的右心室中清楚地看到细胞内钙下降的短期减速阶段被平滑。对照组和高血压组大鼠双心室心肌细胞复极期时间缩短；然而，对照大鼠的右心室样本总是高于高血压大鼠的心肌。在这里，我们首次展示了遗传性动脉高血压大鼠心肌机电耦合某些特征的年龄相关变化。这些实验数据表明自发性肥大的发展可能是由肾素-血管紧张素系统的激活引起的。