Inorganic arsenic exposure has been linked to the development of several health conditions, including adverse birth outcomes, and around 150 million of people worldwide are exposed to levels above the WHO suggested limit of 10 μg/L. A recent risk assessment in pregnant women of Tacna, of this same population performed by our group, found that 70.25% were exposed to arsenic concentrations in drinking water ≥ 25 μg/L. The present study aimed to evaluate the relationship between prenatal total urinary arsenic (U-tAs) and inorganic arsenic (U-iAs) with adverse birth outcomes. A total of 147 pregnant women from the province of Tacna, Peru, during February–March, 2019, were evaluated for U-tAs and U-iAs exposure during their second trimester of pregnancy, while the birth records of their children were collected from the local hospital. The geometric mean U-tAs was 43.97 ± 25.88 μg/L (P₅₀ 22.30, range 5.99–181.94 μg/L) and U-iAs was 5.27 ± 2.91 μg/L. Controlling for maternal age, pre-pregnancy BMI, parity, mother’s education, and newborn sex, no relationship was observed between tertile of U-tAs and the birth outcomes considered, although we found an apparent but statistically non-significant dose–response relationship for small for gestational age 2.38% (95% CI 0.003, 0.16), versus 7.32% (95% CI 0.02, 0.21%), and versus 8.57% (95% CI 0.03, 0.25%). This finding requires further evaluation considering other factors such as metabolic arsenic species, additional maternal covariates, and ethnicity.

无机砷暴露与多种健康状况的发展有关，包括不良的出生结果，全世界约有 1.5 亿人暴露于高于 WHO 建议限值 10 μg/L 的水平。最近对我们小组对同一人群的塔克纳孕妇进行的风险评估发现，70.25% 的人接触到饮用水中砷浓度≥ 25 μg/L。本研究旨在评估产前总尿砷 (U-tAs) 和无机砷 (U-iAs) 与不良出生结局之间的关系。2019 年 2 月至 3 月期间，共有 147 名来自秘鲁塔克纳省的孕妇在妊娠中期接受了 U-tAs 和 U-iAs 暴露评估，而她们孩子的出生记录则来自当地医院。₅₀ 22.30，范围 5.99–181.94 μg/L）和 U-iAs 为 5.27 ± 2.91 μg/L。控制母亲年龄、孕前 BMI、产次、母亲受教育程度和新生儿性别后，未观察到 U-tAs 的三分位数与所考虑的出生结果之间存在关系，尽管我们发现了明显但统计学上不显着的剂量反应关系小于胎龄 2.38% (95% CI 0.003, 0.16)，对比 7.32% (95% CI 0.02, 0.21%) 和 8.57% (95% CI 0.03, 0.25%)。这一发现需要进一步评估，考虑其他因素，如代谢砷种类、额外的母体协变量和种族。