Glioblastoma (GBM) is one of the most malignant primary brain tumors. This neoplasm is the hardest to treat and has a bad prognosis. Because of the characteristics of genetic heterogeneity and frequent recurrence, a successful cure for the disease is unlikely. Increasing evidence has revealed that the GBM stem cell-like cells (GSCs) and microenvironment are key elements in GBM recurrence and treatment failure. To better understand the mechanisms underlying this disease and to develop more effective therapeutic strategies for treatment, suitable approaches, techniques, and model systems closely mimicking real GBM conditions are required. Microfluidic devices, a model system mimicking the in vivo brain microenvironment, provide a very useful tool to analyze GBM cell behavior, their correlation with tumor malignancy, and the efficacy of multiple drug treatment. This paper reviews the applications of microfluidic devices in GBM research and summarizes progress and perspectives in this field.

中文翻译：

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微流体装置在胶质母细胞瘤研究中的应用：现状和未来方向。

胶质母细胞瘤（GBM）是恶性程度最高的原发性脑肿瘤之一。这种肿瘤是最难治疗的，预后也很差。由于遗传异质性和频繁复发的特点，该病不太可能成功治愈。越来越多的证据表明，GBM 干细胞样细胞 (GSC) 和微环境是 GBM 复发和治疗失败的关键因素。为了更好地理解这种疾病的潜在机制并开发更有效的治疗策略，需要合适的方法、技术和模型系统来密切模仿真实的 GBM 条件。微流体装置是一种模拟体内大脑微环境的模型系统，为分析 GBM 细胞行为及其与肿瘤恶性肿瘤的相关性提供了非常有用的工具，和多种药物治疗的疗效。本文综述了微流控器件在 GBM 研究中的应用，并总结了该领域的进展和前景。