Smart materials such as stimuli responsive polymeric hydrogels offer unique possibilities for tissue engineering and regenerative medicine. As, however, most synthetic polymer systems and their degradation products lack complete biocompatibility and biodegradability, this study aims to synthesize a highly magnetic responsive hydrogel, based on the abundant natural biopolymer collagen. As the main component of vertebratal extracellular matrix, it reveals excellent biocompatibility. In combination with incorporated magnetic iron oxide nanoparticles, a novel smart nano-bio-ferrogel can be designed. While retaining its basic biophysical properties and interaction with living cells, this collagen-nanoparticle hydrogel can be compressed to 38% of its original size and recovers to 95% in suitable magnetic fields. Besides the phenomenology of this scenario, the underlying physical scenarios are also discussed within the framework of network models. The observed reversible peak strains a...

中文翻译：

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胶原蛋白-氧化铁纳米颗粒铁凝胶：具有生物激活潜力的大型可逆磁性菌株

诸如刺激响应性聚合物水凝胶之类的智能材料为组织工程和再生医学提供了独特的可能性。但是，由于大多数合成聚合物系统及其降解产物均缺乏完全的生物相容性和生物降解性，因此本研究旨在基于丰富的天然生物聚合物胶原蛋白，合成具有高磁性的水凝胶。作为椎骨细胞外基质的主要成分，它具有出色的生物相容性。结合掺入的磁性氧化铁纳米粒子，可以设计出一种新型的智能纳米生物铁凝胶。在保留其基本生物物理特性以及与活细胞相互作用的同时，这种胶原蛋白-纳米颗粒水凝胶可压缩至其原始大小的38％，并在适当的磁场中恢复至95％。除了这种情况的现象学之外，还在网络模型的框架内讨论了基础的物理情况。观察到的可逆峰应变a ...